Tools and Resources for Circular Dichroism Spectroscopy
نویسندگان
چکیده
منابع مشابه
Circular dichroism and synchrotron radiation circular dichroism spectroscopy: tools for drug discovery.
CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug binding, and detection of potential candidates for new pharmaceuticals. The binding of the anti-tumour agent Taxol to the anti-apo...
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In the near future, design of a new generation of drugs targeting proteins will be required. Considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. So far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. In these studies, use of spectroscopic method...
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Conventional circular dichroism (cCD) spectroscopy is a valuable tool for secondary structure analyses of proteins. In recent years, it has been possible to use synchrotrons as light sources for CD, with the technique being known as Synchrotron Radiation Circular Dichroism (SRCD). In this study, the spectra of two proteins, the primarily helical myoglobin and the primarily beta-sheet concanaval...
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We describe the roles of multiple electronic continua in high-harmonic generation from aligned molecules. First, we show how the circularity of emitted harmonics tracks the interplay of different electronic continua participating in the nonlinear response. Second, we show that the interplay of different continua can lead to large variations of harmonic phases. Finally, we show how multiple elec...
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Circular dichroism (CD) spectroscopy is by far the most widely used technique for protein secondary structure analysis. A survey of the scientific literature will reveal that Robert Woody (Fig. 1) has undoubtedly been a pioneer in the elucidation of the relationship between CD and protein structure and
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.2610